The best agent frameworks for AI agents

Microsoft's framework for multi-agent conversation, with a programming model for agents that talk to each other and tools. Best for conversational multi-agent.

Role-playing autonomous agents that collaborate as a 'crew' with defined roles, goals, and task delegation. Best for role-based multi-agent teams.

Data framework for connecting LLMs to private data — indexing, retrieval, and agentic RAG over your documents. Best for RAG.

Batteries-included agent runtime — built-in memory, knowledge/RAG, and AgentOS, a control plane you run in your own cloud. Formerly Phidata. Best for full-stack agents.

Graph-based orchestration for stateful, multi-actor agent workflows with explicit control flow and checkpointing. Best for stateful multi-agent workflows.

Programming — not prompting — language models: compile declarative pipelines into optimized prompts/weights. Best for prompt optimization.

OpenAI's lightweight agent framework — a small set of primitives (Agents, Handoffs, Guardrails, Sessions); provider-agnostic via LiteLLM. Evolved from Swarm. Best for minimal orchestration.

Google's Agent Development Kit — a code-first, model-agnostic toolkit for building, evaluating, and deploying multi-agent systems. Optimized for Gemini. Best for multi-agent systems.

Type-safe agent framework from the Pydantic team — structured outputs, dependency injection, and model-agnostic agents. Best for type-safe agents.

Anthropic's SDK for building agents on Claude — the harness behind Claude Code, with in-process tools, hooks, and an interactive client. Formerly the Claude Code SDK. Best for Claude-native agents.

AWS's model-driven agent SDK — give it a prompt and tools and let the model plan, call tools, and reflect in a loop. First-class Bedrock, MCP-native, OpenTelemetry tracing. Best for AWS/Bedrock agents.

TypeScript-first SDK for stateful agents where each agent is a Durable Object — embedded SQLite, WebSockets, cron scheduling, and hibernation, running globally on Cloudflare's edge. Best for edge AI agents.